Functional connectivity between salience, default mode and frontoparietal networks in post-stroke depression
Vladislav Balaev1, Ivan Orlov2, Alexey Petrushevsky2
1Institute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences, Moscow, Russian Federation.
Journal of Affective Disorders
|November 24, 2017
Summary
Altered functional brain connectivity in post-stroke depression (PSD) mirrors findings in major depressive disorder (MDD). Resting-state functional connectivity (rsFC) analysis reveals network-level changes in PSD, offering insights into brain network dysfunction.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Previous studies indicate altered resting-state functional connectivity (rsFC) in post-stroke depression (PSD).
- It is unclear if rsFC changes occur at the network level in PSD, similar to major depressive disorder (MDD).
Purpose of the Study:
- To investigate rsFC within resting-state networks (RSNs) in patients with PSD.
- To determine if network-level rsFC alterations in PSD align with those observed in MDD.
Main Methods:
- fMRI scans were conducted on 11 PSD subjects before and after treatment.
- Functional network connectivity (FNC), region of interest - FC (ROI-FC), and brain matter volumes were analyzed.
- Depression severity was assessed using the aphasic depression rating scale (ADRS).
Main Results:
- Positive correlation found between FNC of anterior default mode network (aDMN) and salience network (SAL) with depression severity.
- Treatment led to decreased FNC between aDMN and left frontoparietal network (LFP).
- ROI-FC and brain matter volumes in DMN, LFP, and SAL correlated with ADRS or changed post-treatment.
Conclusions:
- Altered rsFC in PSD is consistent with findings in MDD.
- This convergence supports the use of rsFC for studying brain network dysfunctions in these psychiatric conditions.
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