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Digoxin and Hypermagnesuria.

Luca Zanoli1, Paolo Lentini2, Pasquale Fatuzzo1

  • 1Department of Clinical and experimental Medicine, Section of Nephrology, University of Catania, Catania, Italy.

Nephron
|November 24, 2017
PubMed
Summary
This summary is machine-generated.

Digoxin administration can cause hypermagnesuria (excess magnesium in urine), increasing hypomagnesemia risk. Clinicians should monitor magnesium levels and consider supplementation during digoxin treatment.

Keywords:
DigoxinHypermagnesuriaHypomagnesemiaProton pump inhibitorsSide effects

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Area of Science:

  • Nephrology
  • Pharmacology
  • Biochemistry

Background:

  • Digoxin, a cardiac glycoside, targets the Na+/K+-ATPase γ-subunit.
  • Recent findings suggest digoxin administration induces hypermagnesuria.
  • Hypermagnesuria can lead to hypomagnesemia, a condition with significant clinical implications.

Purpose of the Study:

  • To review the causes of hypermagnesuria.
  • To discuss drug interactions that potentiate digoxin-induced hypermagnesuria.
  • To provide clinical recommendations for managing magnesium levels during digoxin therapy.

Main Methods:

  • Literature review on hypermagnesuria.
  • Analysis of drug interactions affecting magnesium balance.
  • Discussion of clinical implications and management strategies.

Main Results:

  • Digoxin administration is associated with increased urinary magnesium excretion (hypermagnesuria).
  • Co-administration with proton pump inhibitors or loop diuretics may exacerbate magnesium loss.
  • Inherited or acquired conditions can increase susceptibility to digoxin-induced hypomagnesemia.

Conclusions:

  • Clinicians must consider potential causes of hypomagnesemia and hypermagnesuria when prescribing digoxin.
  • Monitoring of serum and urinary magnesium levels is crucial.
  • Oral magnesium supplementation may be necessary to prevent or treat hypomagnesemia.