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The desmoid tumor. Not a benign disease
M C Posner1, M H Shiu, J L Newsome
1Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Archives of Surgery (Chicago, Ill. : 1960)
|February 1, 1989
Summary
Aggressive therapy is necessary for desmoid tumors, which are malignant soft-tissue neoplasms. Recurrent disease and inadequate surgical margins independently predict local tumor recurrence, impacting survival.
Area of Science:
- Oncology
- Surgical Pathology
- Radiation Oncology
Background:
- Desmoid tumors, a type of soft-tissue neoplasm, require evaluation for optimal treatment strategies.
- The necessity of aggressive therapeutic approaches for desmoid tumors remains unclear.
Purpose of the Study:
- To assess the therapeutic value of surgical resection and radiation therapy for desmoid tumors.
- To identify predictive factors for local tumor failure and recurrence.
Main Methods:
- Retrospective analysis of 138 patients diagnosed with desmoid tumors between 1965 and 1984.
- Univariate and multivariate analyses were employed to determine factors associated with local recurrence.
Main Results:
- Five factors predicted local failure: age (18-30), recurrent disease, incomplete resection, close margins, and lack of radiation for residual disease.
- Recurrent disease and inadequate resection margins were independent predictors of recurrence.
- Five-year survival was 92%, with 11 deaths attributed to uncontrolled local tumor growth.
Conclusions:
- Desmoid tumors are malignant neoplasms demanding aggressive treatment.
- Early and complete surgical resection with appropriate adjuvant therapy is crucial for managing desmoid tumors.