Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A cross-correlator-based timing tool for FemtoMAX.

Journal of synchrotron radiation·2025

Same author

Assessing salivary cortisol and testosterone as non-invasive biomarkers for GnRH-immunocastration efficiency in heavy pigs.

BMC veterinary research·2025

Same author

Spontaneous urinary bladder rupture in a dog with lymphoplasmacytic cystitis.

The Journal of small animal practice·2025

Same author

miR-210 overexpression increases pressure overload-induced cardiac fibrosis.

Non-coding RNA research·2025

Same author

Primary uterine large granular lymphocyte lymphoma in an ovariectomised cat.

The Journal of small animal practice·2025

Same author

Estimating the proportion of health care workers susceptible to measles infection in a large university hospital in Milan, Italy, 2019-2023.

Journal of medical virology·2024

Search research articles

Related Experiment Video

Updated: Feb 18, 2026

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

Ovarian Embryonal Carcinoma in a Dog.

B Banco¹, R Ferrari¹, D Stefanello¹

¹Dipartimento di Medicina Veterinaria, Università degli Studi di Milano, Via C. Festa 9, Arenzano GE, Italy.

Journal of Comparative Pathology

|November 25, 2017

Summary

A rare embryonal carcinoma (EC), a type of primitive germ cell tumor, was diagnosed in a young Doberman Pinscher. This aggressive ovarian tumor highlights the need for considering EC in young dogs with ovarian masses.

Keywords:

dog embryonal carcinoma immunohistochemistry ovary

More Related Videos

Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells

Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells

Published on: December 9, 2016

Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells

Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells

Published on: December 16, 2018

Related Experiment Videos

Last Updated: Feb 18, 2026

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis

Published on: July 18, 2016

Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells

Murine Experimental Model of Original Tumor Development and Peritoneal Metastasis via Orthotopic Inoculation with Ovarian Carcinoma Cells

Published on: December 9, 2016

Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells

Derivation and Differentiation of Canine Ovarian Mesenchymal Stem Cells

Published on: December 16, 2018

Area of Science:

Veterinary Pathology
Comparative Oncology
Canine Reproductive Pathology

Background:

Ovarian tumors are relatively uncommon in dogs, but can be aggressive and present with varied clinical signs.
Primitive germ cell tumors, such as embryonal carcinoma, are rare in domestic animals, making diagnosis challenging.

Observation:

A 17-month-old Doberman Pinscher presented with an abdominal mass and ascites, indicative of advanced disease.
Exploratory laparotomy revealed a large ovarian tumor with extensive metastasis to the mesovarium, mesometrium, and peritoneum.
Histopathological examination showed an infiltrative tumor with both round and polygonal cells, high mitotic activity, and evidence of emboli.

Findings:

Immunohistochemistry confirmed the diagnosis of ovarian embryonal carcinoma (EC) by identifying specific markers: placental alkaline phosphatase in round cells and cytokeratins (CK AE1/AE3, CK7) in polygonal cells.
The tumor exhibited features of rudimentary epithelial differentiation, characteristic of primitive germ cell tumors.
Metastatic spread was evident, underscoring the aggressive nature of this canine ovarian tumor.

Implications:

Canine ovarian embryonal carcinoma should be considered in the differential diagnosis for aggressive, undifferentiated ovarian tumors in young dogs.
This case expands the understanding of rare germ cell tumors in veterinary oncology.
Accurate diagnosis through histopathology and immunohistochemistry is crucial for appropriate management and prognosis in affected animals.