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Sweat mechanisms and dysfunctions in atopic dermatitis
Aleksi J Hendricks1, Alexandra R Vaughn2, Ashley K Clark3
1University of Arizona College of Medicine, Tucson, AZ, USA.
Journal of Dermatological Science
|November 25, 2017
Summary
Skin barrier dysfunction in atopic dermatitis (AD) is linked to abnormal eccrine sweat. Understanding sweat
Area of Science:
- Dermatology
- Immunology
- Physiology
Background:
- Atopic dermatitis (AD) is characterized by skin barrier dysfunction.
- Eccrine sweat is a crucial component of the skin's protective barrier.
- Altered sweat responses are increasingly recognized as factors in AD pathogenesis.
Purpose of the Study:
- To review the role of eccrine sweat in atopic dermatitis pathogenesis.
- To examine abnormal sweat composition, secretion, and neuro-immune responses in AD.
- To highlight the therapeutic potential of sweat management in AD.
Main Methods:
- Literature review of studies on skin barrier function in AD.
- Analysis of research on eccrine sweat composition and dynamics in AD patients.
- Examination of neuro-immune interactions related to sweat in atopic skin.
Main Results:
- Skin barrier defects in AD are associated with variations in sweat responses.
- Abnormalities in sweat composition and secretion are evident in individuals with AD.
- Neuro-immune dysregulation in response to sweat contributes to AD exacerbation.
Conclusions:
- Eccrine sweat plays a significant role in the pathogenesis of atopic dermatitis.
- Targeting sweat abnormalities and improving sweat management may offer therapeutic benefits for AD.
- Further research into sweat's role in AD is warranted.
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