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Does pigmentation affect the trabecular meshwork?

D H Johnson1

  • 1Department of Ophthalmology, Mayo Clinic, Rochester, Minn. 55905.

Archives of Ophthalmology (Chicago, Ill. : 1960)
|February 1, 1989
PubMed
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Pigment dispersion in the eye does not affect trabecular meshwork cells. This study found no differences in cell count or appearance between pigmented and non-pigmented areas of the trabecular meshwork.

Area of Science:

  • Ophthalmology
  • Cell Biology
  • Glaucoma Research

Background:

  • Pigment dispersion is linked to glaucoma, particularly in pigment dispersion syndrome and with intraocular lenses.
  • Segmental pigmentation in the trabecular meshwork offers a model to investigate pigment's ocular effects.

Purpose of the Study:

  • To investigate potential differences in trabecular meshwork cellularity and morphology between pigmented and non-pigmented areas in human eyes.

Main Methods:

  • Examined nine human eye bank eyes with segmental trabecular meshwork pigmentation.
  • Assessed cellularity using four quantitative methods: cells per section, per tissue length, per area, and per solid tissue.
  • Compared cellular morphology between pigmented and non-pigmented trabecular meshwork regions.

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Main Results:

  • No significant differences in trabecular meshwork cellularity were observed between pigmented and non-pigmented areas, regardless of the quantification method used.
  • Trabecular meshwork cell morphology also showed no discernible differences between the two regions.
  • The simplest method (cells per histologic section) provided results comparable to more complex methods.

Conclusions:

  • Segmental pigmentation of the trabecular meshwork in human eyes does not appear to alter cellularity or morphology.
  • These findings suggest that pigment deposition alone may not be a primary factor in trabecular meshwork dysfunction in certain conditions.