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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Inflammation01:38

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Updated: Feb 18, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
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Wound healing.

Peng-Hui Wang1, Ben-Shian Huang2, Huann-Cheng Horng3

  • 1Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Obstetric and Gynecology, National Yang-Ming University, Taipei, Taiwan, ROC; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC.

Journal of the Chinese Medical Association : JCMA
|November 25, 2017
PubMed
Summary
This summary is machine-generated.

This review explores recent advancements in wound healing, focusing on fetal versus adult healing, prostaglandins, and the causes and treatments for excessive scarring like hypertrophic scars and keloids.

Keywords:
PathophysiologyWound healing

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Area of Science:

  • Regenerative Medicine
  • Dermatology
  • Physiology

Background:

  • Wound healing is a critical physiological process involving distinct phases: hemostasis/inflammation, proliferation, and remodeling.
  • Disruptions in wound healing can lead to conditions like hypertrophic scars, keloids, or chronic ulcers, impacting physical function.
  • Recent research has significantly advanced our understanding of wound healing mechanisms and therapeutic interventions.

Purpose of the Study:

  • To provide a comprehensive overview of wound healing research published after 2010.
  • To detail the differences between fetal and adult wound healing processes.
  • To explore the role of prostaglandins and the pathogenesis, epidemiology, and therapeutic strategies for excessive wound healing.

Main Methods:

  • Literature review focusing on studies published from 2010 onwards.
  • Analysis of research on fetal and adult wound healing.
  • Synthesis of data on prostaglandins, excessive wound healing pathogenesis, epidemiology, in vitro/in vivo studies, stem cell therapy, and prevention strategies.

Main Results:

  • Fetal wound healing exhibits unique characteristics compared to adult healing, often resulting in scarless outcomes.
  • Prostaglandins play a significant role in modulating the inflammatory and proliferative phases of wound healing.
  • Excessive wound healing, including hypertrophic scars and keloids, involves complexPathways, with emerging stem cell therapies showing promise.

Conclusions:

  • Understanding the nuances of wound healing, particularly in fetal development, offers insights into preventing and treating aberrant scarring.
  • Targeting prostaglandin pathways and exploring novel stem cell therapies are key strategies for managing excessive wound healing.
  • A multi-faceted approach combining current knowledge with emerging research is essential for optimizing wound healing outcomes and preventing complications.