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Related Concept Videos

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Related Experiment Video

Updated: Feb 18, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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Injectable hydrogels for delivering biotherapeutic molecules.

Ansuja Pulickal Mathew1, Saji Uthaman2, Ki-Hyun Cho3

  • 1Department of Biomedical Sciences, BK 21 PLUS Center for Creative Biomedical Scientists at Chonnam National University, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju 61469, Republic of Korea.

International Journal of Biological Macromolecules
|November 25, 2017
PubMed
Summary

Injectable hydrogels offer advanced therapeutic delivery, overcoming limitations of traditional systems. These biocompatible carbohydrate-based materials provide sustained release and improved patient comfort for drug, gene, and cell therapies.

Keywords:
Carbohydrate polymersDrug deliveryInjectable hydrogel

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Traditional therapeutic delivery systems face limitations in efficiency and sustained release.
  • Hydrogels, as 3D networks of hydrophilic polymers, offer biocompatibility and tunable properties for drug delivery.
  • In situ forming injectable hydrogels provide spatial and temporal control, enhancing therapeutic efficacy and patient compliance.

Purpose of the Study:

  • To review the diverse aspects of injectable hydrogels for therapeutic delivery.
  • To highlight the importance of carbohydrate polymers in synthesizing these advanced delivery systems.
  • To discuss the potential of injectable hydrogels in complementing existing therapeutic delivery strategies.

Main Methods:

  • Review of literature on hydrogel synthesis and applications in drug, gene, and cell delivery.
  • Discussion of different hydrogel types: bulk hydrogels/macrogels, microgels, and nanogels.
  • Focus on hydrogels derived from natural polymers, particularly carbohydrate polymers.

Main Results:

  • Injectable hydrogels enable precise control over drug/gene delivery and cell encapsulation.
  • Carbohydrate-based hydrogels demonstrate excellent biocompatibility and desirable physicochemical properties.
  • These systems can form depots in vivo, facilitating sustained therapeutic release and improving patient outcomes.

Conclusions:

  • Injectable hydrogels represent a significant advancement in therapeutic delivery systems.
  • Their tunable nature and biocompatibility make them ideal for sustained release of drugs, genes, and cells.
  • Further development of these systems holds great promise for improving clinical treatments and patient care.