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Pancreatic enzyme replacement therapy after gastric resection: An update

Filippo Antonini¹, Stefano Crippa², Massimo Falconi²

¹Department of Gastroenterology, A. Murri Hospital, Polytechnic University of Marche, Fermo, Italy.

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

|November 25, 2017

Abstract:

Exocrine pancreatic insufficiency (EPI) is one of the possible mechanisms of fat maldigestion following gastric surgery, together with reduced food intake, loss of gastric reservoir, small bowel bacterial overgrowth and rapid small bowel transit. Oral pancreatic enzyme replacement therapy (PERT) is the mainstay of treatment for EPI. The efficacy and safety of pancreatic enzyme substitution in patients following gastric resection remains unclear. This review article summarizes relevant studies addressing PERT after gastric resection.

Keywords:

Exocrine pancreatic insufficiency Gastrectomy Pancreatic enzyme Surgery

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