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Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Work disability in gout: a population-based case-control study.

Valgerdur Sigurdardottir^1,2, Panagiota Drivelegka¹, Anna Svärd²

¹Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Annals of the Rheumatic Diseases

|November 25, 2017

Summary

This summary is machine-generated.

Patients with gout experience significantly higher work absenteeism and societal costs due to lost productivity. Gout is a key predictor of new-onset work disability, even after accounting for other factors.

Keywords:

economic evaluations epidemiology gout

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Area of Science:

Rheumatology
Occupational Health
Health Economics

Background:

Gout is a common inflammatory arthritis.
Work disability represents a significant burden on individuals and society.

Purpose of the Study:

To quantify work disability extent and costs in gout patients compared to controls.
To identify predictors of work disability in gout patients.

Main Methods:

Regional cohort study using Swedish registries (2000-2012).
Included 4571 working-age gout patients and 22,482 matched controls.
Analyzed work-loss days and predictors of new-onset absenteeism.

Main Results:

Gout patients had more comorbidities, lower income, and education.
Work absenteeism was higher in gout patients (22%) vs. controls (14%).
Gout independently predicted new-onset absenteeism (OR 1.47).

Conclusions:

Gout is linked to substantial work absenteeism and societal costs from lost productivity.
Socioeconomic factors and comorbidities also predict work disability.
Cost-effectiveness of intensive gout treatment requires further investigation.