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Association of Autism Spectrum Disorders and Inflammatory Bowel Disease
Maunoo Lee1,2,3, Jayasree Krishnamurthy4, Apryl Susi4
1Department of Pediatrics, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, USA. maunoolee@gmail.com.
Journal of Autism and Developmental Disorders
|November 25, 2017
Summary
Autism spectrum disorder (ASD) is more common in children with inflammatory bowel disease (IBD). This study confirms a link between ASD and IBD, including Crohn's disease and ulcerative colitis.
Area of Science:
- Gastroenterology
- Neurodevelopmental Disorders
- Public Health
Background:
- Autism spectrum disorder (ASD) and inflammatory bowel disease (IBD) share complex origins and gut-brain connections.
- Previous research suggests a potential association between ASD and IBD.
Purpose of the Study:
- To investigate the association between ASD and IBD.
- To utilize strict diagnostic criteria for IBD to confirm this relationship.
Main Methods:
- A retrospective case-cohort study was performed.
- Data were sourced from the Military Health System database.
- IBD diagnosis required an ICD-9-CM code and IBD medication prescription.
Main Results:
- Children diagnosed with ASD showed a higher likelihood of meeting IBD criteria.
- This increased prevalence was observed for both Crohn's disease (CD) and Ulcerative Colitis (UC).
Conclusions:
- The findings confirm a significant association between ASD and IBD.
- Children with ASD have a higher prevalence of CD and UC compared to their peers.
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