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Sex-related relationships between uric acid and target organ damage in hypertension

Alessandro Maloberti1,2, Simone Maggioni2, Lucia Occhi1,2

  • 1Cardiology IV, "A.De Gasperis" Department, ASTT GOM Niguarda Ca' Granda, Milan, Italy.

Journal of Clinical Hypertension (Greenwich, Conn.)
|November 25, 2017
PubMed

Insights

Serum uric acid (SUA) impacts hypertension-related organ damage, particularly renal function. Hyperuricemia is linked to kidney damage and other cardiovascular issues, suggesting SUA

Area of Science:

  • Nephrology
  • Cardiology
  • Hypertension Research

Background:

  • The relationship between serum uric acid (SUA) and target organ damage (TOD) in hypertensive patients is complex and yields inconsistent findings.
  • Understanding this association is crucial for managing cardiovascular and renal risks in hypertension.

Purpose of the Study:

  • To investigate the association between serum uric acid levels and various forms of target organ damage in a cohort of hypertensive patients.
  • To determine if hyperuricemia is an independent predictor of cardiac, arterial, and renal damage in hypertension.

Main Methods:

  • Cross-sectional study of 762 consecutive hypertensive patients.
  • Assessment of clinic blood pressure, serum uric acid (SUA), and cardiac, arterial (carotid, aortic), and renal target organ damage (TOD).
  • Hyperuricemia defined as SUA >7.0 mg/dL in men and >6.0 mg/dL in women.

Main Results:

  • Hyperuricemic men showed lower estimated glomerular filtration rates (eGFR) and higher carotid plaque prevalence.
  • Hyperuricemic women exhibited lower eGFR and increased intima-media thickness.
  • While most TODs correlated with SUA, only eGFR remained significantly determined by SUA in multivariate analysis.

Conclusions:

  • Serum uric acid plays a significant role in the development of renal damage in hypertensive patients.
  • SUA may indirectly influence other TODs by increasing blood pressure and reducing glomerular filtration rate.

Keywords:
albuminuriaarterial hypertensionarterial stiffnesscarotid plaquekidney damageleft ventricular mass indexpulse wave velocitytarget organ damageuric acid

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