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Related Concept Videos

Birth Control Methods01:22

Birth Control Methods

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Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
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Intrauterine Drug Delivery Systems01:21

Intrauterine Drug Delivery Systems

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Controlled-release systems for intravaginal and intrauterine drug delivery have been developed primarily for the administration of contraceptive steroid hormones. These delivery routes circumvent first-pass hepatic metabolism, thereby enhancing bioavailability and allowing for reduced systemic dosages compared to oral administration. Such approaches contribute to improved therapeutic efficacy and patient compliance, particularly in long-term contraceptive regimens.Intravaginal Drug Delivery...
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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...
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Related Experiment Video

Updated: Feb 18, 2026

Methods for Studying Uterine Contributions to Pregnancy Establishment in an Ovariectomized Mouse Model
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Contraception Update: Progestin-Only Implants and Injections.

Prium Deshmukh, Karen Antell1, Elizabeth J Brown2

  • 1Christiana Care Family Medicine Residency Program, 1401 Foulk Road, Suite 100 Wilmington, Delaware 19803.

FP Essentials
|November 28, 2017
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Summary
This summary is machine-generated.

Progestin-only contraceptives, like implants and injections, offer effective long-term birth control. While generally safe, menstrual changes are common, with minimal evidence of weight gain or bone density loss.

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Area of Science:

  • Reproductive Health
  • Contraception
  • Endocrinology

Background:

  • Progestin-only contraception is widely used globally for birth control.
  • Implants and injections provide long-term reversible options.
  • These methods are suitable for postpartum, breastfeeding, and post-abortion use.

Purpose of the Study:

  • To review the efficacy and safety of progestin-only implants and injections.
  • To summarize common adverse effects and contraindications.
  • To assess risks associated with long-term use.

Main Methods:

  • Literature review of progestin-only contraceptive methods.
  • Analysis of clinical data on implants and depot medroxyprogesterone acetate (DMPA) injections.
  • Evaluation of adverse event profiles and safety data.

Main Results:

  • Progestin implants are highly effective with few contraindications; menstrual changes are the most common side effect.
  • Depot medroxyprogesterone acetate (DMPA) injections are effective, but can cause bleeding changes and reversible bone mineral density loss.
  • Weight gain risk with DMPA is higher in obese adolescents and Black patients.
  • No significant increased cancer risk or safety concerns in postpartum/breastfeeding periods.

Conclusions:

  • Progestin-only implants and DMPA injections are effective and safe long-term contraceptive options.
  • Monitoring for menstrual irregularities and bone density is advised for DMPA users.
  • Both methods are suitable for various reproductive stages and populations.