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Impact of hyperhomocysteinemia on insulin resistance in patients with H-type hypertension

Yan Zhang1, Guang Wang1, Jia Liu1

  • 1a Department of Endocrinology, Beijing Chao-Yang Hospital , Capital Medical University , Beijing , P. R. of China.

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|November 28, 2017
PubMed

Insights

Hyperhomocysteinemia (HHcy) significantly worsens insulin resistance, particularly in patients with H-type hypertension (HT). The combined effects of HHcy and HT amplify metabolic dysfunction, increasing cardiovascular disease and stroke risk.

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Health

Background:

  • Hypertension (HT) and hyperhomocysteinemia (HHcy) are linked to insulin resistance.
  • H-type HT, a condition combining HT and HHcy, presents a unique challenge in understanding metabolic dysfunction.
  • The specific impact of HHcy on insulin resistance in H-type HT patients requires further elucidation.

Purpose of the Study:

  • To investigate the relationship between hyperhomocysteinemia and insulin resistance.
  • To assess the impact of H-type hypertension on insulin resistance.
  • To determine the interactive effects of hyperhomocysteinemia and hypertension on insulin resistance.

Main Methods:

  • Recruited 790 patients categorized into control, HHcy, HT, and H-type HT groups.
  • Assessed insulin resistance using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR).
  • Analyzed the correlation between Hcy levels, blood pressure, and HOMA-IR, employing linear regression.

Main Results:

  • Insulin resistance (HOMA-IR) was significantly higher in HHcy and H-type HT groups compared to controls.
  • H-type HT patients exhibited more severe insulin resistance than those with HT alone.
  • Positive correlations were observed between Hcy levels and HOMA-IR, with HHcy and HT showing a multiplicative effect on insulin resistance.

Conclusions:

  • Hyperhomocysteinemia exacerbates insulin resistance, especially in individuals with H-type hypertension.
  • The synergistic effect of HHcy and HT on metabolic dysfunction may explain elevated risks for cardiovascular disease and stroke.
  • Targeting HHcy in hypertensive patients could be crucial for managing metabolic health and reducing cardiovascular risks.
Abstract

Keywords:
Cardiovascular diseasehyperhomocysteinemiahypertensioninsulin resistancemetabolic disease

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