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Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

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Related Experiment Video

Updated: Feb 18, 2026

Human Egg Maturity Assessment and Its Clinical Application

Human Egg Maturity Assessment and Its Clinical Application

Published on: August 19, 2019

Morphometric analysis of human oocytes using time lapse: does it predict embryo developmental outcomes?

Azita Faramarzi^1,2, Mohammad Ali Khalili¹, Marjan Omidi¹

¹a Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences , Yazd , Iran.

Human Fertility (Cambridge, England)

|November 28, 2017

Summary

Oocyte size and shape (morphometrics) do not reliably predict embryo development after ICSI. However, ooplasm diameter may help predict embryo cleavage timing in IVF.

Keywords:

Embryo irregular cleavage morphokinetic oocyte morphometry time lapse

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Published on: September 3, 2021

Area of Science:

Reproductive biology
Embryology
In vitro fertilization

Background:

Oocyte quality is crucial for successful fertilization and embryo development.
Intra-cytoplasmic sperm injection (ICSI) is a common IVF technique.
Predicting embryo development can optimize selection for transfer.

Purpose of the Study:

To investigate the relationship between metaphase II (MII) oocyte morphometric parameters and subsequent embryo morphokinetics following ICSI.
To determine if oocyte morphology can predict embryo development and selection in ICSI cycles.

Main Methods:

Prospective study evaluating MII oocyte morphometry (ooplasm diameter, zona pellucida width, etc.).
Assessment of embryo morphokinetic variables (pronuclear appearance, cleavage times, irregular divisions).
Statistical analysis to correlate oocyte parameters with embryo development milestones.

Main Results:

Oocyte morphometric parameters, including ooplasm diameter, showed a significant relationship with specific embryo cleavage timings (tPB2, t5, t8).
No significant associations were found between overall oocyte morphometry and other key morphokinetic parameters or embryo arrest.
Oocyte morphometry did not prove to be a reliable predictor for embryo selection in ICSI cycles.

Conclusions:

Morphometric parameters of MII oocytes are not sufficient for predicting embryo morphokinetics or for embryo selection in ICSI.
Ooplasm diameter may serve as a potential marker for predicting the timing of embryo cleavage during IVF.