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Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
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MYC leads the way.

Niranjan Venkateswaran1, Maralice Conacci-Sorrell1,2

  • 1Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX, USA.

Small Gtpases
|November 28, 2017
PubMed
Summary
This summary is machine-generated.

MYC oncogenes drive cancer progression by promoting cell proliferation and metabolic changes. This review explores MYC

Keywords:
EMTMYCMYC-nickmetastasismigration

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • MYC proto-oncogenes are frequently deregulated in human cancers.
  • MYC proteins are key drivers of tumor initiation, progression, and cancer hallmarks.
  • MYC's role in metabolic reprogramming supports tumor cell proliferation and biomass accumulation.

Purpose of the Study:

  • To review the role of MYC in cancer invasion.
  • To discuss MYC's canonical functions in Epithelial to Mesenchymal Transition (EMT).
  • To explore cytoplasmic functions of MYC-nick in collective cell migration.

Main Methods:

  • Literature review of MYC's functions in cancer progression.
  • Analysis of MYC's role as a transcription factor.
  • Investigation of MYC's cytoplasmic pro-survival functions.

Main Results:

  • MYC regulates tumor progression, chemotherapy resistance, and metastasis.
  • Canonical MYC functions involve Epithelial to Mesenchymal Transition (EMT).
  • Emerging evidence highlights cytoplasmic MYC roles in invasion and migration.

Conclusions:

  • MYC is a critical regulator of multiple cancer hallmarks, including invasion.
  • Understanding MYC's diverse functions, both nuclear and cytoplasmic, is crucial for cancer therapy.
  • MYC-nick's cytoplasmic role in collective migration warrants further investigation.