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Functional morbidity after regional isolated perfusion of the limb for melanoma

A N van Geel1, J van Wijk, J Wieberdink

  • 1Department of Surgical Oncology, Dr. Daniel den Hoed Cancer Center, Rotterdam, The Netherlands.

Cancer
|March 15, 1989
PubMed

Insights

Regional isolated perfusion (RIP) for high-risk melanoma showed minimal subjective limb complaints. Objective assessments revealed good limb condition, though some joint mobility issues were noted, particularly in the lower leg.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Clinical Research

Background:

  • High-risk melanoma requires effective treatment strategies.
  • Regional isolated perfusion (RIP) is a therapeutic option.
  • Assessing long-term limb morbidity after RIP is crucial.

Purpose of the Study:

  • To evaluate functional limb morbidity in patients post-melanoma RIP.
  • To investigate long-term outcomes and complications.

Main Methods:

  • Retrospective analysis of 57 patients with Stage I-II high-risk melanoma.
  • Follow-up assessment of limb function after RIP.
  • Subjective patient-reported complaints and objective clinical examinations.

Main Results:

  • Median follow-up of 5 years.
  • Only one patient reported severe limb complaints.
  • 80% of upper limbs and 64% of lower limbs showed no edema or atrophy.
  • Joint mobility restrictions were observed, more prevalent in lower limbs, with over 25% severe ankle restriction.

Conclusions:

  • Regional isolated perfusion for high-risk melanoma appears to have a favorable subjective limb morbidity profile.
  • Objective limb assessment reveals generally good outcomes, but potential for joint mobility impairment, especially in lower extremities, warrants attention.

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