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Genetic variation of haptoglobin and transferrin in relation to DNA content and stage in renal cell carcinoma
N Fröhlander1, B Ljungberg, G Roos
1Department of Medical Genetics, University of Umeå, Sweden.
Cancer
|March 15, 1989
Abstract:
Four genetic marker systems were investigated in 102 patients with renal cell carcinoma. The previously observed excess of the transferrin (TF) variant C3 among male patients was confirmed. Interestingly, an excess of TFC3 and a deficit of the haptoglobin heterozygote, HP2-1, were associated with diploid tumor DNA content and Stage I, particularly in male patients. The results are discussed in terms of a possible genetic influence on tumor progression.