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Phonological working memory and FOXP2.

Katrin Schulze1, Faraneh Vargha-Khadem2, Mortimer Mishkin3

  • 1UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK; Clinical Psychology and Psychotherapy Unit, Department of Psychology, Heidelberg University, Hauptstraße 47-51, 69117 Heidelberg, Germany.

Neuropsychologia
|November 28, 2017
PubMed
Summary
This summary is machine-generated.

The FOXP2 gene mutation impacts speech and language. Affected individuals show deficits in phonological working memory, suggesting issues with subvocal rehearsal and speech-based representations.

Keywords:
FOXP2KE familyPhonological memorySpeech impairmentWorking memory

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Area of Science:

  • Genetics
  • Neuroscience
  • Cognitive Science

Background:

  • The FOXP2 gene is crucial for human speech and language development.
  • Mutations in FOXP2 cause speech and language disorders, such as verbal and orofacial dyspraxia.
  • The impact of FOXP2 mutations on cognitive processes beyond direct speech production, like working memory, remains unclear.

Purpose of the Study:

  • To investigate the effect of the FOXP2 mutation on Working Memory (WM) components.
  • To determine if individuals with the FOXP2 mutation exhibit deficits in phonological loop (PL), visuospatial sketchpad (VSSP), or central executive (CE) functions.
  • To explore the relationship between impaired phonological WM and speech production deficits.

Main Methods:

  • Utilized a test series based on the Baddeley and Hitch WM model.
  • Compared WM performance across CE, PL, and VSSP components in affected KE family members (aKE) and healthy controls.
  • Assessed both motor output and recognition-based tasks within the PL component.

Main Results:

  • Affected KE family members (aKE) scored significantly lower on the phonological loop (PL) component of working memory compared to controls.
  • No significant differences were found in visuospatial sketchpad (VSSP) or central executive (CE) functions between groups.
  • aKE individuals demonstrated impairments in both articulatory motor output and recognition-based phonological tasks.

Conclusions:

  • The FOXP2 mutation is associated with impaired phonological working memory.
  • Deficits in phonological WM may stem from a defect in subvocal rehearsal of speech-based material.
  • Compromised speech-based representations could underlie the observed phonological working memory impairments in individuals with FOXP2 mutations.