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Published on: May 14, 2013
Acute myocardial infarction in a 25-year-old woman with sitosterolemia
Ryuki Kawamura1, Hitoshi Saiki1, Hayato Tada2
1Department of Cardiology, Tokyo Metropolitan Health Medical Treatment Corporation, Toshima Hospital, Tokyo, Japan.
Abstract:
We report the case of acute myocardial infarction in a 25-year-old woman with sitosterolemia. She was treated using statins, but her low-density lipoprotein cholesterol (LDL-C) levels did not decrease appreciably. Genetic analysis revealed mutations in the ABCG8 gene. Ezetimibe treatment was initiated, and her LDL-C levels decreased substantially. Sitosterolemia must be considered in the differential diagnosis of familial hypercholesterolemia in case of early onset cardiovascular disease patient with high LDL-C.
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