Related Experiment Video
Updated: Nov 19, 2025

Disruption of the Blood-Spinal Cord Barrier Using Low-Intensity Focused Ultrasound in a Rat Model
Published on: March 10, 2023
Lumbar Medial Branch Block Volume-Dependent Dispersion Patterns as a Predictor for Ablation Success: A Cadaveric
Sayed E Wahezi1,2,3,4, Edward Alexeev1,2,3,4, John S Georgy1,2,3,4
1Department of Physical Medicine and Rehabilitation, Montefiore Medical Center, 1250 Waters Place, Tower Two, 8th Floor, Bronx, NY 10461.
Using a smaller injectate volume of 0.25 mL for lumbar medial branch blocks can improve specificity for radiofrequency ablation (RFA) planning by minimizing spread to adjacent nerves. Larger volumes (0.5 mL) may lead to false positives in diagnosing low back pain.
Area of Science:
- Anatomy
- Pain Management
- Radiology
Background:
- Lumbar facet arthropathy is a frequent cause of low back pain.
- Radiofrequency ablation (RFA) is a common treatment for lumbar facet arthropathy.
- Diagnostic blocks are used to predict RFA success but have high false-positive rates.
Purpose of the Study:
- To investigate how injectate volume affects the spread of lumbar medial branch blocks.
- To determine if smaller volumes (0.25 mL) offer greater specificity than larger volumes (0.5 mL).
- To assess the impact of injectate volume on the accuracy of diagnostic blocks for RFA.
Main Methods:
- A cadaveric study was conducted using six lumbar spines.
- Fluoroscopically guided medial branch injections were performed with 0.25 mL and 0.5 mL volumes.
- Post-injection CT imaging and dissection were used to analyze injectate spread.
Main Results:
- Both 0.25 mL and 0.5 mL volumes adequately covered the medial branches.
- The 0.5 mL volume showed significant spread to adjacent muscles and distal nerve segments.
- The 0.25 mL volume remained localized to the deep and intermediate lumbar muscle layers.
Conclusions:
- A 0.5 mL injectate volume may cause unintended blocks of adjacent nerves, reducing diagnostic accuracy.
- A 0.25 mL injectate volume reliably targets lumbar medial branches with minimal spread.
- Using 0.25 mL for lumbar medial branch blocks may enhance specificity for RFA planning.
Related Concept Videos
Local Anesthetics: Clinical Application as Spinal Anesthesia
Local Anesthetics: Differential Sensitivity of Nerve Fibers
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
One of the advantages of...

