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Longitudinal changes in cranial base angulation in mandibulofacial dysostosis
S J Peterson-Falzone1, A A Figueroa
1Center for Craniofacial Anomalies, University of California, San Francisco.
The Cleft Palate Journal
|January 1, 1989
Summary
Cranial base angulation in patients with mandibulofacial dysostosis (MFD) often worsens over time, leading to basilar kyphosis. This progressive change, more common in males, highlights the time-dependent nature of abnormal cranial base angles in MFD.
Area of Science:
- Craniofacial development
- Orthodontics
- Genetics
Background:
- Mandibulofacial dysostosis (MFD) is a congenital disorder affecting facial bone development.
- Cranial base angulation plays a crucial role in craniofacial structure and growth.
- Longitudinal studies are essential to understand the dynamic changes in MFD.
Purpose of the Study:
- To investigate the longitudinal changes in cranial base angulation in patients with MFD.
- To determine the prevalence and progression of basilar kyphosis in MFD.
- To identify potential factors influencing cranial base angle changes over time.
Main Methods:
- Longitudinal cephalometric analysis of the nasion-sella-basion (N-S-Ba) angle.
- Study included 24 patients with MFD with records spanning 2 to 29 years.
- Analysis of initial and final measurements, considering age at record acquisition.
Main Results:
- Five patients presented with basilar kyphosis (N-S-Ba < 120 degrees) at initial measurement.
- Twenty-one patients showed increasing cranial base angle (CBA) flexion over time.
- By final records, 54% of patients exhibited kyphotic CBA; males predominated in those with significant changes.
Conclusions:
- Abnormal cranial base angulation in MFD can be time-dependent, developing or worsening over years.
- Progressive basilar kyphosis is a significant finding in a majority of MFD patients studied.
- Male gender may be associated with more pronounced longitudinal changes in CBA in MFD.