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Engineering cell wall synthesis mechanism for enhanced PHB accumulation in E. coli

Xing-Chen Zhang1, Yingying Guo1, Xu Liu1

  • 1MOE Lab for Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.

Metabolic Engineering
|November 28, 2017
PubMed
Summary

Altering bacterial cell wall rigidity impacts poly-3-hydroxybutyrate (PHB) accumulation. Weakening cell walls in E. coli enhances PHB production, while strengthening them reduces it, offering new avenues for microbial morphology engineering.

Keywords:
Bacterial cell wallCRISPRiCell wall synthesis genesEscherichia coliInclusion bodiesPHBPolyhydroxyalkanoatesftsWmurE

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