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Updated: Feb 18, 2026

Preparation of Horizontal Slices of Adult Mouse Retina for Electrophysiological Studies

Preparation of Horizontal Slices of Adult Mouse Retina for Electrophysiological Studies

Published on: January 27, 2017

Local Signals in Mouse Horizontal Cell Dendrites.

Camille A Chapot¹, Christian Behrens², Luke E Rogerson²

¹Institute for Ophthalmic Research, University of Tübingen, 72076 Tübingen, Germany; Center for Integrative Neuroscience, University of Tübingen, 72076 Tübingen, Germany; Graduate Training Centre of Neuroscience, University of Tübingen, 72076 Tübingen, Germany.

Current Biology : CB

|November 28, 2017

Summary

This summary is machine-generated.

Mouse horizontal cells process cone signals locally, not globally. This local feedback shapes cone output temporal properties, challenging previous assumptions about their function in vision.

Keywords:

calcium cone photoreceptor dendrite feedback glutamate horizontal cell mouse retina

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Area of Science:

Neuroscience
Vision Science
Retinal Physiology

Background:

Mouse retina has one horizontal cell type, a GABAergic interneuron.
Horizontal cells modulate cone photoreceptor output via feedback.
Electrically coupled horizontal cells were thought to perform global signal processing.

Purpose of the Study:

Investigate if horizontal cells process cone input locally.
Determine if signals from individual cones remain isolated or spread within horizontal cells.
Assess the role of local horizontal cell feedback in cone signal processing.

Main Methods:

Two-photon microscopy to record Ca2+ signals in cone terminals and horizontal cell dendrites.
Measurement of glutamate release in the outer plexiform layer.
Selective stimulation of mouse cone opsins (M-opsin and S-opsin) using green and UV light.
Biophysically realistic modeling.

Main Results:

Ca2+ signals in horizontal cell dendrites showed chromatic preference based on opsin expression (dorsal: M-opsin, ventral: S-opsin).
Neighboring horizontal cell dendritic tips exhibited varied chromatic preferences, indicating local processing.
Removal of horizontal cells reduced cone signal sensitivity to low frequencies.

Conclusions:

Horizontal cells process cone input locally, extending their known function.
Local horizontal cell feedback influences the temporal properties of cone output.
Findings challenge the notion of solely global signal processing by horizontal cells.