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RBFOX1, encoding a splicing regulator, is a candidate gene for aggressive behavior.

Noèlia Fernàndez-Castillo1, Gabriela Gan2, Marjolein M J van Donkelaar3

  • 1Departament de Genètica, Microbiologia i Estadística, Facultat de Biologia, Universitat de Barcelona, Barcelona, Catalonia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Spain; Institut de Biomedicina de la Universitat de Barcelona (IBUB), Barcelona, Catalonia, Spain; Institut de Recerca Sant Joan de Déu (IR-SJD), Esplugues de Llobregat, Catalonia, Spain.

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
|November 28, 2017
PubMed
Summary
This summary is machine-generated.

The RBFOX1 gene is linked to aggressive behavior, with evidence from human genetic studies, animal models, and neuroimaging. Further research is needed to fully understand its role in this complex trait.

Keywords:
A2BP1AggressionAnimal modelsEpigeneticsGenetics, TranscriptomicsNeuroimagingRBFOX1

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Area of Science:

  • Neuroscience
  • Genetics
  • Behavioral Science

Background:

  • The RBFOX1 gene (RNA binding fox-1 homolog 1) is crucial for neuronal development and has been associated with autism spectrum disorder and other neurodevelopmental conditions.
  • Existing evidence from multiple sources suggests a potential role for RBFOX1 in aggressive behavior, although this link requires further investigation.

Purpose of the Study:

  • To comprehensively review and synthesize the cumulative evidence linking the RBFOX1 gene to aggressive behavior.
  • To present new findings that further implicate RBFOX1 in the phenotype of aggression.

Main Methods:

  • Review of genetic and epigenetic association studies (GWAS, EWAS) in humans.
  • Analysis of neuroimaging genetics data examining temporal lobe volume.
  • Examination of gene expression data and findings from animal models of aggression (Drosophila, mice).

Main Results:

  • Suggestive associations between RBFOX1 and aggression-related phenotypes (anger, conduct disorder) identified in human GWAS.
  • Nominal association signals for RBFOX1 found in an epigenome-wide association study of aggressive behavior.
  • RBFOX1 variants impact temporal lobe volume, a brain region implicated in aggression; animal studies demonstrate its modulation of aggressive behavior.

Conclusions:

  • The cumulative evidence, while largely nominal and requiring caution, consistently implicates RBFOX1 in aggressive behavior across human and animal studies.
  • The hypothesis-free nature of many studies strengthens the findings, but further research is essential to elucidate the precise mechanisms by which RBFOX1 influences aggression.