Related Experiment Video
Updated: Feb 18, 2026
10:04
A Zebrafish Embryo Model for In Vivo Visualization and Intravital Analysis of Biomaterial-associated Staphylococcus aureus Infection
Published on: January 7, 2019
7.5K
Staphylococcus aureus and Staphylococcus epidermidis infections on implants
W F Oliveira1, P M S Silva1, R C S Silva2
1Departamento de Bioquímica, Centro de Biociências, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
The Journal of Hospital Infection
|November 28, 2017
Summary
Implant infections caused by Staphylococcus aureus and Staphylococcus epidermidis are common. Strategies to prevent biofilm formation on implant surfaces, like surface modification and antimicrobial compounds, are crucial for patient health.
Area of Science:
- Medical Microbiology
- Biomaterials Science
- Infectious Diseases
Background:
- Implant-related infections are a significant cause of implant removal, necessitating complex and costly treatments.
- Staphylococcus aureus and Staphylococcus epidermidis are the primary bacterial pathogens identified in these infections.
- Understanding the epidemiology and pathogenesis of these infections is critical for developing effective prevention and treatment strategies.
Purpose of the Study:
- To review the epidemiology and pathogenesis of implant-related infections caused by Staphylococcus aureus and Staphylococcus epidermidis.
- To discuss methodologies for identifying antibiofilm compounds.
- To explore strategies for modifying biomaterial surfaces to prevent bacterial adhesion and infection.
Main Methods:
- Systematic literature search of PubMed, ScienceDirect, Academic Google, and CAPES Journal Portal.
- Review of epidemiological studies focusing on S. aureus and S. epidermidis implant infections.
- Discussion of in-vitro biofilm quantification methods (e.g., crystal violet assay) and surface modification techniques.
Main Results:
- S. aureus and S. epidermidis are frequently implicated in infections associated with catheters, orthopedic, and breast implants.
- Crystal violet staining is a cost-effective and reproducible method for in-vitro biofilm quantification.
- Surface modifications, including antibiotic immobilization, silver functionalization, natural compounds, and electrical treatment, show promise in preventing biofilm formation.
Conclusions:
- Effective prevention of implant-related infections requires strategies targeting biofilm formation on biomaterial surfaces.
- Surface modification techniques offer promising avenues to combat S. aureus and S. epidermidis infections.
- Continued research into novel antibiofilm compounds and surface functionalization is essential to improve implant outcomes.
Related Concept Videos
01:30Bacterial Signaling
41.6K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
41.6K
01:25Endocarditis I: Introduction
552
Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
552
01:26Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
5.9K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
5.9K
01:19Clinical Applications of Epidermal Stem Cells
3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
01:23Skin Diseases and Disorders
5.7K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.7K