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Related Experiment Video

Updated: Feb 18, 2026

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Superwettable microchips with improved spot homogeneity toward sensitive biosensing.

Yanxia Chen1, Li-Ping Xu1, Jingxin Meng2

  • 1Research Center for Bioengineering and Sensing Technology, Beijing Key Laboratory for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, PR China.

Biosensors & Bioelectronics
|November 28, 2017
PubMed
Summary

Researchers developed a superwettable microchip for sensitive biomarker detection. This innovation improves spot homogeneity, enabling accurate and reliable analysis of samples like free prostate-specific antigen (f-PSA).

Keywords:
BiomarkerBiosensingSpot homogeneitySuperhydrophilicSuperhydrophobicSuperwettable microchip

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Area of Science:

  • Materials Science
  • Biotechnology
  • Analytical Chemistry

Background:

  • High-quality spots on microchips are crucial for sensitive and accurate biomarker detection.
  • Existing methods face challenges with sample homogeneity and detection limits.

Purpose of the Study:

  • To develop a superwettable micropattern for improved sample distribution and homogeneous spot formation.
  • To create a sensitive and specific microchip for detecting free prostate-specific antigen (f-PSA).

Main Methods:

  • Constructed a superwettable micropattern with superhydrophilic microwells on a superhydrophobic substrate.
  • Utilized enhanced Marangoni effect and a 3D nanodendritic silica structure to suppress outward flow.
  • Developed a free prostate-specific antigen (f-PSA) microchip based on the superwettable micropattern.

Main Results:

  • Achieved homogeneous sample distribution and deposit spots after droplet evaporation.
  • Developed a superwettable f-PSA microchip with high sensitivity, specificity, and long-term stability.
  • Reached a limit of detection as low as 10 fg/mL for f-PSA.
  • Demonstrated accurate detection in human serum samples, correlating well with clinical methods.

Conclusions:

  • The superwettable micropattern significantly improves spot homogeneity, leading to sensitive and accurate fluorescence readout.
  • The developed f-PSA microchip shows great potential as a reliable sensing platform for biological analysis and clinical diagnosis.