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PPP2R5A: A multirole protein phosphatase subunit in regulating cancer development

Ziming Mao1, Chunying Liu1, Xuejing Lin1

  • 1Department of Molecular Oncology, Eastern Hepatobiliary Surgical Hospital & National Center of Liver Cancer, Second Military Medical University, Shanghai, 200438, China.

Cancer Letters
|November 28, 2017
PubMed

Insights

Protein phosphatase 2, regulatory subunit B (B56), alpha isoform (PPP2R5A) is crucial for protein phosphatase 2A (PP2A) function. This review explores PPP2R5A

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • Protein phosphatase 2A (PP2A) is a key serine/threonine phosphatase involved in numerous cellular processes.
  • PPP2R5A, a regulatory subunit of PP2A, modulates PP2A's localization, substrate specificity, and enzymatic activity.
  • Dysregulation of PPP2R5A is implicated in various diseases, particularly cancers, with underlying mechanisms requiring further elucidation.

Purpose of the Study:

  • To review the role of PPP2R5A in cellular functions.
  • To summarize the association between PPP2R5A and the development and progression of tumors.
  • To highlight the potential of PPP2R5A as a target for cancer prevention, diagnosis, and therapy.

Main Methods:

  • Literature review of studies investigating PPP2R5A.
  • Analysis of research linking PPP2R5A to cancer.
  • Synthesis of findings on PPP2R5A's role in cellular signaling pathways relevant to tumorigenesis.

Main Results:

  • PPP2R5A influences critical cellular activities through its regulation of PP2A.
  • Evidence suggests a significant correlation between PPP2R5A and various cancer types.
  • The precise molecular mechanisms connecting PPP2R5A to cancer progression are still under investigation.

Conclusions:

  • PPP2R5A is a vital regulator of PP2A with a significant role in cellular homeostasis.
  • Understanding PPP2R5A's involvement in tumorigenesis is crucial for developing novel cancer treatments.
  • Further research into PPP2R5A mechanisms can improve cancer early diagnosis, targeted therapy, and patient prognosis.
Keywords:
Molecular mechanismPPP2R5AProtein phosphataseSignaling pathwayTumor

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