Design and simulation of a microfluidic device for acoustic cell separation
1Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran.
Ultrasonics
|November 28, 2017
Summary
This study simulates acoustic cell separation using finite element analysis. The method effectively sorts white blood cells and platelets from blood, offering a cost-effective design optimization tool.
Area of Science:
- Biomedical Engineering
- Acoustic Cell Separation
Background:
- Acoustic cell separation is widely used for blood cell separation.
- Numerical simulation of acoustic cell separation requires further investigation for device optimization and cost reduction.
Purpose of the Study:
- To present a finite element-based simulation of acoustic separation for platelets, red blood cells, and white blood cells.
- To investigate the use of standing surface acoustic waves (SSAWs) for cell separation.
Main Methods:
- A microfluidic channel with three inlets and two interdigital transducers was designed.
- Finite element analysis was used to simulate acoustic radiation force and particle trajectories.
- The simulation utilized standing surface acoustic waves (SSAWs) to exert force on cells based on size.
Main Results:
- Two distinct separation modes were observed by varying acoustic field amplitude.
- White blood cells were sorted through the middle outlet in the first mode.
- Platelets were sorted through the side outlets in the second mode.
Conclusions:
- The finite element simulation provides a low-cost method for optimizing acoustic cell separation devices.
- The microfluidic device can be adapted for clinical needs to separate specific blood cell types.
- Simulation of acoustic radiation force and particle trajectories is crucial for device design.
