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Anti-Müllerian Hormone: genetic and environmental effects
Seyedeh Zahra Shahrokhi1, Faranak Kazerouni2, Firouzeh Ghaffari3
1Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Abstract:
Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein produced by granulosa cells of growing ovarian follicles. AMH appears to have an inhibitory effect on both primordial follicle recruitment and responsiveness of growing follicles to follicle-stimulating hormone (FSH). This hormone is considered to be a reliable marker of ovarian reserve; therefore, it is crucial to determine which factors influence AMH levels for prognostic and diagnostic purposes. In this review we intend to discuss the effect of genetic and environmental factors which may lead to AMH interindividual variability.
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