Recent developments in anti-Trichomonas research: An update review

Area of Science:

• Microbiology
• Pharmacology
• Infectious Diseases

Background:

• Trichomonas vaginalis causes a significant non-viral sexually transmitted infection.
• Obstetrical and gynecological complications are associated with trichomoniasis.
• Increasing resistance to nitroimidazole therapy and high recurrence rates necessitate alternative treatments.

Purpose of the Study:

• To review synthetic and natural products with anti-Trichomonas activity.
• To identify potential alternatives to metronidazole for trichomoniasis treatment.
• To consolidate research on combating Trichomonas vaginalis from 2006 to 2017.

Main Methods:

• Systematic literature search of electronic databases.
• Data collection from 2006 to June 2017.
• Review of published research on synthetic and natural products against Trichomonas vaginalis.

Main Results:

• A substantial body of research exists on synthetic and natural products for trichomoniasis.
• Various compounds show potential anti-Trichomonas activity.
• The review synthesizes findings on metronidazole alternatives.

Conclusions:

• There is a growing need for novel therapeutic agents against Trichomonas vaginalis.
• Synthetic and natural products represent promising avenues for new drug development.
• Further research is warranted to develop effective metronidazole alternatives for trichomoniasis.