Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A modified scintigraphic technique for amputation level selection in diabetics.

B J Dwars1, J A Rauwerda, T A van den Broek

  • 1Department of Vascular Surgery, Free University Hospital Amsterdam, The Netherlands.

European Journal of Nuclear Medicine
|January 1, 1989
PubMed
Summary

A modified 123I-antipyrine washout technique improves amputation level selection by measuring skin perfusion pressure (SPP) and skin blood flow (SBF). This method offers objective data, enhancing healing outcomes for patients with peripheral vascular disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effectiveness of a Stigma Awareness Intervention on Reemployment of People with Mental Health Issues/Mental Illness: A Cluster Randomised Controlled Trial.

Journal of occupational rehabilitation·2023
Same author

Patient-reported outcomes after incisional hernia repair.

Hernia : the journal of hernias and abdominal wall surgery·2021
Same author

Serum fatty acid chain length associates with prevalent symptomatic end-stage osteoarthritis, independent of BMI.

Scientific reports·2020
Same author

Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells.

Osteoarthritis and cartilage·2016
Same author

Shift in responsibilities in diabetes care: the Nurse-Driven Diabetes In-Hospital Treatment protocol (N-DIABIT).

Diabetic medicine : a journal of the British Diabetic Association·2015
Same author

Follow-up after laparoscopic inguinal hernia repair, can it be done by phone? A prospective study in 300 patients, the PINQ-PHONE.

Surgical endoscopy·2015

Area of Science:

  • Nuclear Medicine
  • Vascular Surgery
  • Diabetic Foot Care

Background:

  • Amputation level selection is critical for healing in patients with diabetic foot complications.
  • Peripheral vascular disease significantly impacts wound healing after amputation.
  • Current methods for assessing tissue perfusion may lack accuracy or convenience.

Purpose of the Study:

  • To describe a modified 123I-antipyrine cutaneous washout technique for improved amputation level selection.
  • To evaluate the correlation between skin perfusion pressure (SPP) and skin blood flow (SBF) with healing outcomes.
  • To assess the predictive value of SPP for successful amputation wound healing.

Main Methods:

  • A modified 123I-antipyrine washout technique was developed, allowing simultaneous recordings and reducing examination time.

Related Experiment Videos

  • Skin perfusion pressure (SPP) and skin blood flow (SBF) were measured preoperatively in 26 diabetic patients with foot ulcers or gangrene.
  • Measurements were taken at the selected amputation level and adjacent sites.

    • Main Results:

    • The modified technique determined both SPP and SBF from clearance curves.
    • Low SBF values correlated with low SPP values, indicating peripheral vascular disease.
    • Amputations healed in all cases with SPP > 20 mmHg, while 2/3 failed with SPP < 20 mmHg.
    • SPP measurements could have altered amputation levels in 6 of 17 major lower limb amputations.

    Conclusions:

    • The modified 123I-antipyrine washout technique provides accurate, objective data for selecting optimal amputation levels.
    • SPP is a reliable predictor of successful wound healing following amputation.
    • This technique enhances patient acceptance and reduces examination time, improving clinical utility.