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Serum progranulin levels in relation to insulin resistance in childhood obesity

Eman M Alissa1, Rima H Sutaih1, Hayat Z Kamfar1

  • 1.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|November 28, 2017
PubMed

Insights

Elevated serum progranulin levels in children are linked to increased adiposity, insulin resistance, and inflammation. Progranulin may serve as a valuable biomarker for childhood obesity and associated metabolic disturbances.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Syndrome Research
  • Adipokine Signaling

Background:

  • Progranulin, an adipokine, influences inflammation, glucose metabolism, and insulin resistance.
  • Childhood obesity is associated with chronic subclinical inflammation.
  • Progranulin's role in childhood obesity pathogenesis warrants investigation.

Purpose of the Study:

  • To investigate the association between circulating progranulin levels and metabolic parameters in children.
  • To evaluate progranulin as a potential biomarker for metabolic diseases in pediatric populations.

Main Methods:

  • 150 children were recruited from pediatric nutrition clinics.
  • Children were stratified into four groups based on serum progranulin quartiles.
  • Anthropometric measurements, fasting glucose, insulin, and lipid profiles were assessed.

Main Results:

  • Children in the highest progranulin quartile exhibited greater adiposity, insulin resistance, and elevated lipids and C-reactive protein.
  • Serum progranulin correlated significantly with adiposity, metabolic parameters, inflammation, and insulin resistance markers.
  • Adiposity measures explained 26.6% of the variability in serum progranulin levels.

Conclusions:

  • Increased serum progranulin concentrations are closely associated with adiposity, metabolic parameters, and insulin resistance in children.
  • Progranulin shows potential as an excellent biomarker for identifying childhood obesity.
  • Further research can explore progranulin's therapeutic implications in pediatric metabolic health.
Abstract

Keywords:
body mass index (BMI)childhood obesityinsulin resistanceprogranulinwaist circumference

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