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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
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Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

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Long-term prognostic impact of left ventricular remodeling after a first myocardial infarction in modern clinical

Christophe Bauters1, Emilie Dubois2, Sina Porouchani3

  • 1University of Lille, Inserm U1167, Institut Pasteur, University Hospital of Lille, Lille, France.

Plos One
|November 28, 2017
PubMed

Insights

Left ventricular remodeling (LVR) after myocardial infarction (MI) significantly increases long-term risks for heart failure (HF) and cardiovascular death, even with optimal secondary prevention medication use.

Area of Science:

  • Cardiology
  • Clinical Medicine
  • Cardiovascular Research

Background:

  • Left ventricular remodeling (LVR) is a known risk factor post-myocardial infarction (MI).
  • Its association with heart failure (HF) and death in patients on optimal secondary prevention requires further study.

Purpose of the Study:

  • To investigate the long-term prognostic significance of LVR after MI.
  • To assess the impact of LVR on cardiovascular death and HF hospitalization in patients receiving contemporary secondary prevention.

Main Methods:

  • Long-term clinical follow-up of patients from two prospective multicentric studies.
  • Echocardiography at 1 year post-MI to assess LVR (≥20% increase in end-diastolic volume).
  • Analysis of cardiovascular death and HF hospitalization rates, adjusted for baseline characteristics.

Main Results:

  • LVR occurred in 31% and 38% of patients across two cohorts.
  • High prescription rates for beta-blockers and ACE-I/ARBs were observed (>90%).
  • LVR was independently associated with a significantly increased risk of cardiovascular death or HF hospitalization (p < 0.01).

Conclusions:

  • Left ventricular remodeling (LVR) remains a significant independent predictor of adverse outcomes post-MI.
  • This association persists despite high adherence to evidence-based secondary prevention therapies.
Abstract

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