[Immunotherapy following habitual abortion in paternal chromosome translocation]

In a 41-year-old VII-gravida, I-para, the husband's reciprocal translocation of the chromosomes 1 and 18 as well as a partial identity of the marital partner in the HLA-system may have been the underlying causes for five abortions. In the 7th pregnancy, a prenatal chromosome analysis was performed as well as an immunotherapy with paternal lymphocytes, when uterine bleeding occurred. After termination of bleeding, the pregnancy continued without any complication. Our case report demonstrates the importance of an extensive search for causes leading to recurrent abortions not only with regard to diagnosis but also with regard to therapy in pregnancy.