Does FeNO Predict Clinical Characteristics in Chronic Cough?
Mahboobeh Haji Sadeghi1, Caroline E Wright1, Simon Hart1
1Respiratory Medicine, Castle Hill Hospital, Institute for Clinical and Applied Health Research (ICAHR), Hull York Medical School, Cottingham, UK.
Purpose:
To evaluate whether exhaled nitric oxide measurement can facilitate in the assessment of chronic cough patients based on their airway inflammatory phenotype.
Methods:
We have studied consecutive patients attending a specialist cough clinic. 30 patients with high FeNO (> 30 ppb) and 20 patients with low FeNO (< 20 ppb) were recruited.
Results:
There was a significant correlation between FeNO, B-Eos and sputum eosinophil count (p < 0.001). The number of recorded coughs in 24 h and HARQ scores were significantly (p < 0.05) higher in patients with a low FeNO. In contrast to the high FeNO group (48%), the greater proportion of these patients were women (90%). LCQ scores were worse in the low FeNO group but it was not significant.
Conclusion:
A strong relationship between FeNO, blood eosinophils and sputum eosinophils confirming phenotypic identity was observed. Whether the observed gender disparity accounts for the different cough frequency characteristics is unknown.
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