Does FeNO Predict Clinical Characteristics in Chronic Cough?
Mahboobeh Haji Sadeghi1, Caroline E Wright1, Simon Hart1
1Respiratory Medicine, Castle Hill Hospital, Institute for Clinical and Applied Health Research (ICAHR), Hull York Medical School, Cottingham, UK.
Lung
|November 28, 2017
Summary
Exhaled nitric oxide (FeNO) measurements correlate with blood and sputum eosinophils in chronic cough patients. Low FeNO levels are linked to increased cough frequency and a higher prevalence of women, suggesting distinct inflammatory phenotypes.
Area of Science:
- Respiratory Medicine
- Clinical Immunology
- Pulmonology
Background:
- Chronic cough is a common clinical problem.
- Airway inflammation plays a key role in chronic cough.
- Identifying inflammatory phenotypes aids targeted treatment.
Purpose of the Study:
- To determine if exhaled nitric oxide (FeNO) measurement can help classify chronic cough patients by airway inflammatory phenotype.
- To investigate the relationship between FeNO levels and other inflammatory markers.
Main Methods:
- Consecutive patients from a specialist cough clinic were studied.
- Patients were divided into high FeNO (>30 ppb) and low FeNO (<20 ppb) groups.
- Correlation analysis was performed between FeNO, blood eosinophils (B-Eos), and sputum eosinophil counts.
Main Results:
- A significant correlation was found between FeNO, B-Eos, and sputum eosinophils (p < 0.001).
- Patients with low FeNO reported significantly more coughs in 24 hours and higher HARQ scores (p < 0.05).
- The low FeNO group predominantly consisted of women (90%) and had worse LCQ scores.
Conclusions:
- FeNO measurement strongly correlates with blood and sputum eosinophils, confirming phenotypic identity in chronic cough.
- Low FeNO levels are associated with increased cough frequency and a distinct demographic profile.
- Further research is needed to understand the gender disparity in cough frequency characteristics.
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