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Direct Observation of Phagocytosis and NET-formation by Neutrophils in Infected Lungs using 2-photon Microscopy
Published on: June 2, 2011
[Increase of phlegmonous forms of infection following angina]
1Universitäts-Hals-Nasen-Ohrenklinik, Essen.
HNO
|January 1, 1989
Abstract:
A sudden mini-epidemic of severe septic cervical soft tissue phlegmons following pharyngitis with thrombophlebitis of the jugular veins, mediastinitis and meningeal irritation posed problems of diagnosis and therapy because the typical symptoms were masked by the preceding treatment with antibiotics. The disease could only be partially controlled by intensive care. Three illustrative cases are reported.
Insights
A mini-epidemic of severe septic cervical soft tissue phlegmons presented diagnostic challenges due to masked symptoms from prior antibiotic treatment. Intensive care offered only partial disease control in these cases.
Area of Science:
- Infectious Diseases
- Otolaryngology
- Critical Care Medicine
Context:
- A rare cluster of severe septic cervical soft tissue phlegmons occurred following pharyngitis.
- Complications included jugular vein thrombophlebitis, mediastinitis, and meningeal irritation.
- Preceding antibiotic treatment obscured typical clinical presentations.
Purpose:
- To report and analyze three challenging cases of severe septic cervical soft tissue phlegmons.
- To highlight diagnostic and therapeutic difficulties in managing these masked infections.
- To underscore the limitations of intensive care in severe, atypical presentations.
Summary:
- Three patients developed severe septic cervical soft tissue phlegmons after pharyngitis.
- Symptoms were atypical due to prior antibiotic use, complicating diagnosis.
- Intensive care management provided only partial control of the severe infections.
Impact:
- This case series emphasizes the importance of considering unusual presentations of deep neck infections.
- It highlights the challenges in diagnosing and treating infections where typical signs are masked.
- Findings may inform clinical vigilance and management strategies for similar complex cases.
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