Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.3K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.3K
Bone Remodeling01:40

Bone Remodeling

40.6K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.6K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.9K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.9K
The Bone Matrix01:18

The Bone Matrix

5.9K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
5.9K
Bone Disorders01:29

Bone Disorders

5.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.6K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.7K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Emilin2 marks the target region for mesenchymal cell accumulation in bone regeneration.

Inflammation and regeneration·2024
Same author

WAIF1 Is a Cell-Surface CTHRC1 Binding Protein Coupling Bone Resorption and Formation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2018
Same author

A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2017
Same author

Serum CTX levels and histomorphometric analysis in Src versus RANKL knockout mice.

Journal of bone and mineral metabolism·2017
Same author

The role of osteoclast differentiation and function in skeletal homeostasis.

Journal of biochemistry·2015
Same author

Proliferation-coupled osteoclast differentiation by RANKL: Cell density as a determinant of osteoclast formation.

Bone·2015

Related Experiment Video

Updated: Feb 18, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

12.2K

[Coupling of bone resorption and formation.]

Sunao Takeshita1

  • 1Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology, Japan.

Clinical Calcium
|November 28, 2017
PubMed
Summary

Bone remodeling relies on osteoclasts resorbing bone before osteoblasts form new bone. This coupling process, critical for bone health, involves factors from osteoclasts themselves.

Area of Science:

  • Bone Biology
  • Skeletal Physiology
  • Osteoclast-Osteoblast Communication

Background:

  • Bone remodeling maintains bone quantity and quality through coupled resorption and formation.
  • Osteoclastic bone resorption precedes and induces osteoblast-mediated bone formation.
  • The coupling process is essential for skeletal homeostasis.

Purpose of the Study:

  • To investigate the role of osteoclast-derived factors in bone remodeling.
  • To elucidate the mechanisms underlying the coupling of bone resorption and formation.
  • To understand the implications for metabolic bone diseases like osteoporosis.

Main Methods:

  • Review of emerging evidence on osteoclast involvement in coupling.
  • Analysis of molecular factors secreted or presented by osteoclasts.

More Related Videos

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
07:03

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

7.4K
A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

7.5K

Related Experiment Videos

Last Updated: Feb 18, 2026

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

12.2K
A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
07:03

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

7.4K
A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

7.5K
  • Exploration of signaling pathways mediating osteoclast-osteoblast communication.

    • Main Results:

    • Osteoclasts play an active role in initiating bone formation through secreted factors.
    • Specific osteoclast-derived molecules are implicated in the coupling process.
    • Understanding these mechanisms is key to addressing bone loss.

    Conclusions:

    • Osteoclast-derived factors are critical mediators of bone formation following resorption.
    • Elucidating these coupling mechanisms offers therapeutic targets for osteoporosis.
    • This research advances the understanding of bone remodeling and metabolic bone diseases.