Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Remodeling01:40

Bone Remodeling

40.6K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.6K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.3K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Disrupted phosphate metabolism and SIBLING/ASARM peptide accumulation underlie impaired bone mineralization in klotho-deficient (kl/kl) mice.

Bone·2026
Same author

O-GlcNAcylation-mediated glycolytic reprogramming of CD4<sup>+</sup> T cells contributes to type H vessel impairment in diabetic osteoporosis.

Cellular signalling·2026
Same author

Elastin calcification during the initial stage of vascular calcification in kl/kl mice is suppressed by the calcimimetic upacicalcet.

Scientific reports·2026
Same author

Corrigendum to "Histochemical analysis of osteoclast and osteoblast distributions on hydroxyapatite/collagen bone-like nanocomposite embedded in rat tibiae" [J Oral Biosci 67 (2025) 100612].

Journal of oral biosciences·2026
Same author

Potential modulation of ED-71 in regulating H3K18 histone lactylation to suppress osteoclast differentiation and alleviate postmenopausal osteoporosis.

Biochemical pharmacology·2026
Same author

Addition of a collagen mimetic peptide to octacalcium phosphate/gelatin composites enhances bone formation by accelerating calcification.

Acta biomaterialia·2026
Same journal

[The frontier of adipocyte biology, cold environment induces thermogenic genes via epigenomic switch.]

Clinical calcium·2019
Same journal

[Sequential treatment of osteoporosis with anti-sclerostin.]

Clinical calcium·2019
Same journal

[The sequential therapy of romosozumab followed by denosumab for osteoporosis.]

Clinical calcium·2019
Same journal

[Wnt signaling in myeloma.]

Clinical calcium·2019
Same journal

[Fate decision of hematopoietic stem cells by Wnt signaling.]

Clinical calcium·2019
Same journal

[Control of inflammatory bone destruction by targeting the Wnt signaling pathway.]

Clinical calcium·2019
See all related articles

Related Experiment Video

Updated: Feb 18, 2026

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol
04:11

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

Published on: October 27, 2023

1.4K

[Bone remodeling and modeling/mini-modeling.]

Tomoka Hasegawa1, Norio Amizuka1

  • 1Developmental Biology and Hard Tissue, Faculty of Dental Medicine, Hokkaido University,Japan.

Clinical Calcium
|November 28, 2017
PubMed
Summary
This summary is machine-generated.

Bone modeling shapes bone during development, while remodeling replaces old bone in adults. Mini-modeling, a distinct process, forms new bone without resorption, as seen with eldecalcitol and teriparatide.

More Related Videos

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
05:10

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

759
Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

2.0K

Related Experiment Videos

Last Updated: Feb 18, 2026

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol
04:11

Author Spotlight: Insights into an Efficient Murine Maxillary Orthodontic Model Protocol

Published on: October 27, 2023

1.4K
Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
05:10

Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model

Published on: February 7, 2025

759
Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
05:25

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential

Published on: July 21, 2023

2.0K

Area of Science:

  • Orthopedics
  • Cellular Biology
  • Histology

Background:

  • Bone undergoes modeling (shape changes) during development and remodeling (replacement) in adults.
  • Modeling includes macro-modeling and micro-modeling (mini-modeling).
  • Mini-modeling involves osteoblasts depositing new bone without osteoclast-mediated resorption.

Purpose of the Study:

  • To review the histological characteristics of bone remodeling and modeling.
  • To highlight the cellular mechanisms of mini-modeling.
  • To discuss drugs that may induce mini-modeling.

Main Methods:

  • Histological examination of bone tissue.
  • Review of literature on bone modeling and remodeling.
  • Analysis of cellular processes in mini-modeling.

Main Results:

  • Mini-modeling features active osteoblasts on new bone surfaces.
  • Unlike bone remodeling, mini-modeling shows minimal osteoclastic resorption.
  • Drugs like eldecalcitol and teriparatide may induce mini-modeling-based bone formation.

Conclusions:

  • Mini-modeling is a distinct bone formation process.
  • Understanding mini-modeling is crucial for developing osteoporosis treatments.
  • Histological features differentiate mini-modeling from bone remodeling.