[Immobilization and bone remodeling disorder.]
Related Experiment Video
Updated: Feb 18, 2026

Author Spotlight: Comparing Alveolar and Long Bone Remodeling to Explore OTM Model Potential
Published on: July 21, 2023
Manabu Tsukamoto1, Akinori Sakai1
1Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Japan.
Abstract:
Mechanical stress is essential for us to maintain bone volume and structure. Immobilization and unloading, such as motor paralysis, long-term bedrest and casting of fractured area, cause rapidly remarkable bone loss. The bone remodeling disorder following immobilization demonstrates the acceleration of bone resorption and the suppression of bone formation, and molecular mechanism of the bone remodeling disorder has been gradually revealed recently. It is very difficult for us to improve the bone loss due to disuse completely. Thus, prevention of disuse osteoporosis is important. We should choose suitable treatment after considering the pathophysiology of disuse osteoporosis, and attempt early intervention as soon as possible.
More Related Videos
07:35Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
Published on: April 11, 2012
05:10Improved Methodology for Studying Postnatal Osteogenesis via Intramembranous Ossification in a Murine Bone Marrow Injury Model
Published on: February 7, 2025
Related Concept Videos
Bone Remodeling
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Osteoclasts in Bone Remodeling
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
The Functions of the Skeletal System
What is the Skeletal System?