Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.3K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.3K
Bone Remodeling01:40

Bone Remodeling

40.6K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
40.6K
Bone Disorders01:29

Bone Disorders

5.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.6K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.9K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy and safety of sirukumab in Japanese patients with active rheumatoid arthritis who were refractory or intolerant to anti-tumor necrosis factor therapy: Subgroup analysis of a randomized, double-blind, multicenter, phase 3 study (SIRROUND-T).

Modern rheumatology·2018
Same author

IgG4-related Pleuritis with Elevated Adenosine Deaminase in Pleural Effusion.

Internal medicine (Tokyo, Japan)·2018
Same author

Sirukumab in rheumatoid arthritis refractory to sulfasalazine or methotrexate: a randomized phase 3 safety and efficacy study in Japanese patients.

Arthritis research & therapy·2018
Same author

[Homeostasis and Disorder of Musculoskeletal System.Progress in the treatment of rheumatoid arthritis.]

Clinical calcium·2018
Same author

JAK1/JAK2 inhibition by baricitinib in diabetic kidney disease: results from a Phase 2 randomized controlled clinical trial.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association·2018
Same author

Intracranial vessel wall lesions in patients with systematic lupus erythematosus.

Journal of magnetic resonance imaging : JMRI·2018

Related Experiment Video

Updated: Feb 18, 2026

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

996

[Glucocorticoid-induced abnormality in bone remodeling.]

Yoshiya Tanaka1

  • 1The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan.

Clinical Calcium
|November 28, 2017
PubMed
Summary

Glucocorticoid (GC) therapy can lead to severe osteoporosis and bone fractures. Understanding GC

Area of Science:

  • Endocrinology
  • Bone Biology
  • Pharmacology

Background:

  • Glucocorticoids (GC) are vital for treating autoimmune, inflammatory, and allergic conditions.
  • GC therapy frequently results in adverse skeletal effects, notably osteoporosis and fractures.
  • These skeletal complications significantly impact patient quality of life and treatment adherence.

Purpose of the Study:

  • To elucidate the mechanisms underlying Glucocorticoid-induced osteoporosis (GIOP).
  • To highlight the clinical implications of GC's effects on bone metabolism.
  • To emphasize the importance of managing GIOP in patients undergoing GC therapy.

Main Methods:

  • Review of existing literature on GC's effects on bone cells.
  • Analysis of cellular pathways involved in osteoblast and osteoclast function.

More Related Videos

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments
06:16

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments

Published on: May 9, 2019

8.1K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

12.2K

Related Experiment Videos

Last Updated: Feb 18, 2026

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head
05:55

Author Spotlight: Developing a Rat Model for Weight-Bearing Intervention to Investigate Osteonecrosis of the Femoral Head

Published on: September 27, 2024

996
Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments
06:16

Preparation Of Gushukang GSK Granules for In Vivo and In Vitro Experiments

Published on: May 9, 2019

8.1K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

12.2K
  • Synthesis of clinical data regarding fracture risk in GC users.

    • Main Results:

    • GC inhibits mesenchymal stem cell differentiation into osteoblasts.
    • GC promotes apoptosis in mature osteoblasts and osteocytes.
    • GC extends osteoclast lifespan, increasing bone resorption.
    • These actions collectively lead to reduced bone mass and impaired bone micro-architecture.

    Conclusions:

    • GC-induced osteoporosis is a multifactorial condition driven by disrupted bone remodeling.
    • Effective management requires adherence to established guidelines for GIOP treatment.
    • Physicians must proactively monitor and manage skeletal health in patients on long-term GC therapy.