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Muscle acidosis during static exercise is associated with calf vasoconstriction
L Sinoway1, S Prophet, I Gorman
1Department of Medicine and Radiology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.
Journal of Applied Physiology (Bethesda, Md. : 1985)
|January 1, 1989
Summary
Forearm exercise-induced acidosis correlates with calf vasoconstriction. Changes in phosphocreatine-to-inorganic phosphate ratio (PCr/Pi) without pH shifts do not affect calf vascular resistance.
Area of Science:
- Physiology
- Biochemistry
Background:
- Static exercise impacts cardiovascular and metabolic parameters.
- Skeletal muscle metabolism changes during exercise, affecting cellular pH and energy stores.
Purpose of the Study:
- To investigate the relationship between forearm muscle metabolism and calf vascular resistance during and after static exercise.
- To determine if changes in phosphocreatine-to-inorganic phosphate ratio (PCr/Pi) or pH influence calf vascular resistance.
Main Methods:
- Utilized 31P-nuclear magnetic resonance (31P-NMR) to measure PCr/Pi and pH in human forearms.
- Subjects performed static forearm exercise at 30% maximal voluntary contraction (MVC) followed by circulatory arrest.
- Monitored heart rate, blood pressure, and calf vascular resistance.
Main Results:
- Static exercise increased heart rate, blood pressure, and calf vascular resistance.
- Forearm cellular acidosis (decreased pH) was correlated with increased calf vascular resistance.
- Significant reductions in PCr/Pi and pH occurred with exercise and occlusion.
- Large PCr/Pi reductions alone did not alter calf vascular resistance.
Conclusions:
- Forearm cellular acidosis is associated with calf vasoconstriction during static exercise.
- Significant changes in PCr/Pi without concurrent pH alterations are not linked to calf vascular resistance changes.
Keywords:
Non-programmatic