Novel pathomechanisms in inflammatory neuropathies.
David Schafflick1, Bernd C Kieseier2, Heinz Wiendl1
1Department of Neurology, Westfälische Wilhems-University, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.
Journal of Neuroinflammation
|November 29, 2017
Summary
Recent advances in understanding autoimmune inflammatory neuropathies offer hope for new treatments. This review covers current knowledge on targets, immunology, animal models, and future diagnostic and therapeutic strategies.
Area of Science:
- Neuroimmunology
- Peripheral Nervous System Disorders
Background:
- Inflammatory neuropathies are rare autoimmune disorders impacting the peripheral nervous system.
- Understanding their pathomechanisms is crucial for future diagnostic and therapeutic advancements.
Purpose of the Study:
- To summarize current knowledge on antigenic targets and immunological concepts in inflammatory neuropathies.
- To review animal models and emerging diagnostic and therapeutic strategies.
- To highlight the gap between preclinical and clinical findings and suggest future research directions.
Main Methods:
- Literature review of recent research on inflammatory neuropathies.
- Analysis of immunological concepts, antigenic targets, and animal models.
- Evaluation of novel diagnostic tools and therapeutic candidates.
Main Results:
- Significant progress has been made in understanding the immunological basis of inflammatory neuropathies.
- Various animal models exist for studying acute and chronic variants.
- New diagnostic tools like MRI and potential therapies are under development.
Conclusions:
- Bridging the gap between preclinical research and clinical application is essential.
- Future developments in diagnostics and therapeutics hold promise for patients with inflammatory neuropathies.
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