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Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

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Sarcopenia in children with perforated appendicitis.

Joseph J López¹, Jennifer N Cooper², Brett Albert³

¹Department of Surgery, Nationwide Children's Hospital, Columbus, Ohio; Center for Surgical Outcomes Research and the Center for Innovation in Pediatric Practice, The Research Institute at Nationwide Children's Hospital, Columbus Ohio.

The Journal of Surgical Research

|November 29, 2017

Summary

Pediatric complex appendicitis patients experienced sarcopenia, a decrease in skeletal muscle mass, during their hospital stay. This muscle loss may impact surgical outcomes and warrants further investigation for potential interventions.

Keywords:

Computerized tomography Perforated appendicitis Sarcopenia

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Area of Science:

Pediatric surgery
Skeletal muscle physiology
Medical imaging analysis

Background:

Sarcopenia, or decreased skeletal muscle mass, is linked to poor surgical recovery in adults.
The impact of sarcopenia on pediatric surgical patients, particularly those with complicated appendicitis, is not well understood.

Purpose of the Study:

To investigate whether pediatric patients with complicated appendicitis undergo sarcopenic changes during treatment.
To quantify the rate of muscle mass change in these patients.

Main Methods:

Retrospective review of 36 pediatric patients with complex appendicitis.
Analysis of pre- and post-operative computed tomography (CT) scans to measure psoas muscle area.
Utilized linear mixed models to assess changes in muscle area over time.

Main Results:

Patients showed a median decrease in body mass index (BMI) from admission to discharge (-0.8 kg/m²).
A significant daily decrease in psoas muscle area was observed (-0.81% per day, P < 0.001).
Muscle mass decrease did not significantly vary by BMI, gender, or race.

Conclusions:

Pediatric complex appendicitis patients experience sarcopenia during hospitalization.
Further research is needed to determine if this sarcopenia correlates with postsurgical complications.
Investigating interventions to prevent muscle loss in these patients is recommended.