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Polypill, hypertension and medication adherence: The solution strategy?

D Cimmaruta1, N Lombardi2, C Borghi3

  • 1Department of Experimental Medicine, Section of Pharmacology "L. Donatelli", University of Campania Region "Luigi Vanvitelli", Naples, Italy.

International Journal of Cardiology
|November 29, 2017
PubMed

Insights

The polypill approach significantly improves medication adherence in cardiovascular patients. This strategy may help manage hypertension and related conditions, though further real-world studies are needed.

Area of Science:

  • Cardiology
  • Pharmacology
  • Public Health

Background:

  • Hypertension is a major global health issue and a leading preventable risk factor for cardiovascular disease.
  • Challenges in hypertension management include comorbidities and poor patient adherence to medications.
  • The World Health Organization emphasizes improved adherence for cardiovascular disease reduction.

Purpose of the Study:

  • To review evidence on the polypill approach for hypertension management.
  • To assess the impact of polypills on adherence, cardiovascular risk, and safety.

Main Methods:

  • Review of principal observational and clinical trial data.
  • Analysis of studies focusing on adherence, cardiovascular risk reduction, and polypill safety.

Main Results:

  • The polypill approach demonstrably increases adherence compared to standard care for cardiovascular patients.
  • Potential for concomitant reductions in cardiovascular risk factors has been observed.

Conclusions:

  • Polypill use shows promise for patients with hypertension, comorbidities, and adherence issues.
  • Further real-world studies are necessary to fully establish the role of polypills in clinical practice.
Abstract

Keywords:
AdherenceCardiovascular eventsHypertensionLDL-cholesterolPolypillSystolic blood pressure

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