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Updated: Feb 18, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
Using Drug Prescribing Patterns to Identify Stewards of Cost-Conscious Care
Nicole Michele Gastala1, Peter Wingrove2, Winston Liaw2
1From Primary Health Care, Inc., Marshalltown, IA (NMG); Robert Graham Center for Policy Studies, Washington, DC (PW, WL, SP, AB). reizinee@gmail.com.
Purpose:
To characterize family physicians (FPs) who are stewards of care by consistently prescribing omeprazole over esomeprazole.
Methods:
Cross-sectional analysis of physicians prescribing omeprazole or esomeprazole under Medicare Part D in 2014.
Results:
There was a regional trend with 49% of Western FPs but only 6% of Southern FPs rarely prescribing esomeprazole. Physicians had increased odds of being a steward if they worked with a care coordinator (P < .001), at a patient-centered medical home (P < .001), or in a large practice (P < .001).
Conclusions:
If these findings are replicated across multiple drugs, future outreach could be conducted based on provider prescribing patterns.
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