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Analysis of Oxidative Stress in Zebrafish Embryos
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Oxidative stress and prostatic diseases.

Thierry Roumeguère1,2, Joseph Sfeir3, Elie El Rassy4

  • 1Department of Urology, University Clinics of Brussels, Université Libre de Bruxelles, Erasme Hôpital, 187793 Bruxelles, Belgium.

Molecular and Clinical Oncology
|November 29, 2017
PubMed
Summary

Oxidative stress is linked to common male prostatic diseases like benign prostatic hyperplasia and prostatitis. Targeting this pathway offers potential new treatment options for these conditions.

Keywords:
benign prostatic hyperplasiaoxidative stressprostateprostate cancerreactive oxygen species

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Area of Science:

  • Urology
  • Molecular Biology
  • Pathophysiology

Background:

  • Prostatic diseases are prevalent in Western males.
  • Chronic prostatic diseases often have unclear causes and limited treatments.
  • Oxidative stress is implicated in benign prostatic hyperplasia, prostate cancer, and chronic prostatitis.

Purpose of the Study:

  • To systematically review the association between oxidative stress and common chronic prostatic diseases.
  • To describe current treatment options targeting the oxidative stress pathway.

Main Methods:

  • Systematic literature review.
  • Analysis of in vitro and in vivo study data.

Main Results:

  • Oxidative stress is a significant factor in the pathogenesis of major prostatic diseases.
  • The oxidative stress cascade presents a viable therapeutic target.

Conclusions:

  • Oxidative stress plays a key role in chronic prostatic diseases.
  • Targeting oxidative stress pathways is a promising therapeutic strategy for prostatic conditions.