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Antioxidative Effects of Natural Products on Diabetic Cardiomyopathy

Bingdi Yan1, Jin Ren1, Qinghua Zhang1

  • 1Department of Respiratory Medicine, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun 130041, China.

Journal of Diabetes Research
|November 29, 2017
PubMed

Insights

Diabetic cardiomyopathy (DCM) is a serious diabetes complication. This review highlights natural antioxidants that may prevent or treat DCM by targeting oxidative stress.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Diabetic cardiomyopathy (DCM) is a severe diabetes complication with high mortality.
  • Oxidative stress is a primary mechanism driving DCM development.
  • Targeting oxidative stress presents a promising therapeutic avenue for DCM.

Purpose of the Study:

  • To comprehensively review antioxidant natural products for DCM inhibition.
  • To summarize clinical trial data on these natural products in DCM management.
  • To provide discussion and future perspectives on this therapeutic strategy.

Main Methods:

  • Systematic literature search for studies on natural products and DCM.
  • Analysis of antioxidative mechanisms of identified natural products.
  • Inclusion of clinical trial data for DCM management.

Main Results:

  • Several natural products demonstrate beneficial effects in attenuating DCM.
  • Antioxidative mechanisms are key to the efficacy of these natural products.
  • Clinical trials provide evidence for their role in DCM management.

Conclusions:

  • Antioxidant natural products show potential in preventing and inhibiting DCM progression.
  • Targeting oxidative stress via natural products is a viable therapeutic strategy.
  • Further research and clinical validation are warranted.

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