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Autoantibodies to Granulocyte-Macrophage Colony-Stimulating Factor Associated With Severe and Unusual Manifestations

Nancy F Crum-Cianflone1,2,3, Pamela V Lam1, Sarah Ross-Walker4

  • 1Internal Medicine Department.

Open Forum Infectious Diseases
|November 29, 2017
PubMed

Keywords:
GM-CSF autoantibodiescryptococcusimmune deficitsspinal epidural abscess

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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