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Isolation of Extracellular Vesicles from Murine Bronchoalveolar Lavage Fluid Using an Ultrafiltration Centrifugation Technique
Published on: November 9, 2018
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Exosomes and microvesicles in normal physiology, pathophysiology, and renal diseases
Anne-Lie Ståhl1, Karl Johansson1, Maria Mossberg1
1Department of Pediatrics, Clinical Sciences Lund, Lund University, 22185, Lund, Sweden.
Pediatric Nephrology (Berlin, Germany)
|November 29, 2017
Summary
Extracellular vesicles are key in cell communication and kidney disease. These tiny particles can be biomarkers and therapeutic targets for renal conditions, impacting inflammation and repair.
Area of Science:
- Cell Biology
- Renal Medicine
- Biochemistry
Background:
- Extracellular vesicles (EVs) are cell-derived particles involved in intercellular communication.
- EVs are released during various cellular states, including stress and apoptosis.
- They play roles in maintaining cellular integrity by removing harmful substances.
Purpose of the Study:
- To review the biogenesis, uptake, detection, and impact of EVs on recipient cells.
- To focus on EV mechanisms relevant to kidney disease pathophysiology.
- To explore the dual role of EVs in renal disease progression and repair.
Main Methods:
- Literature review of extracellular vesicle research.
- Analysis of EV involvement in kidney disease mechanisms like thrombosis, angiogenesis, and inflammation.
- Examination of EV detection in biological fluids (blood, urine) for biomarker potential.
Main Results:
- Extracellular vesicles are implicated in intercellular communication and cellular homeostasis.
- EVs contribute to kidney disease pathophysiology through mechanisms including thrombosis, inflammation, and immune modulation.
- EVs are detectable biomarkers in blood and urine and possess potential for therapeutic applications in kidney injury.
Conclusions:
- Extracellular vesicles are significant in intercellular communication and have a complex role in kidney diseases.
- EVs can serve as diagnostic biomarkers and therapeutic targets for acute and chronic kidney injury.
- Understanding EV functions offers opportunities for novel drug therapies and regenerative approaches in nephrology.
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